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Programme

 

Tuesday 27th June, 2017

 

13.00-14.00            Registration at Samuelssonsalen Tomtebodavägen 6, Karolinska Institutet 


14.00-14.15            Welcome and introductionBirgitta Henriques-Normark, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

 

Pneumococcal Genomics Chair: Angela Bruggemann

 

14.15-14.45            PL1. The evolution of the pneumococcal accessory genome. 

                               Nicholas Croucher, Department of Infectious Disease Epidemiology, Imperial College London, UK


14.45-15.00            O1.1 Influence of the Pneumococcal Conjugate Vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy 

                               Infants: a longitudinal analysis of a case-control study

                               Markus Hilty, Institut für Infektionskrankheiten, Universität Bern, Bern, Switzerland


15.00-15.15            O1.2 Recombination in Streptococcus pneumoniae lineages increase with carriage duration and size of the polysaccharide capsule. 

                               Chrispin Chaguza,Dept of Clinical Infection, Microbiology and Immunology, Institute of Infection & Global Health, University of Liverpool, Liverpool, UK


15.15-15.30            O1.3  Genome Mining and Transcriptome Analyses of Bacteriocins in Streptococcus pneumoniae. 

                               Reza Rezaei Javan, Nuffield Department of Medicine, University of Oxford, Oxford, UK

 

15.30-16.00            Coffee break

 

Pneumococcal Molecular Microbiology and Genetics Chair: Sven Hammerschmidt

 

16.00-16.30            PL2 Heterogeneity among estimates of the core genome and pan-genome in different pneumococcal populations. 

                               Angela B Brueggemann, NuffieldDepartment of Medicine, University of Oxford, Oxford, UK


 16.30-16.45           O2.1 A regulatory cascade that controls pneumococcal capsule transcription. 

                               Andrew Ulijasz, Department of Microbiology and Immunology, Loyola University Chicago, Chicago, USA


16.45-17.00            O2.2. The two-component regulatory system 08 is involved in regulation of pneumococcal fitness and colonization factors. 

                               Alejandro Gómez-Mejia, Dept. Genetics of Microorganisms, , Ernst Moritz Arndt University of Greifswald, Greifswald, Germany


17.00-17.15            O2.3. Identification of EloR (Spr1851) as a regulator of cell elongation in Streptococcus pneumoniae. 

                               Daniel Straume, The Norwegian University of Life Sciences, Faculty of Chemistry, Biotechnology and Food Science, Ås, Norway


17.15-17.30            O2.4. Identification of new factors governing S. pneumoniae cell wall assembly.

                               Andrew Fenton, Florey Institute, Sheffield, UK

 

17.30-                     Social Mingle with snacks outside Samuelssonsalen 

 

Wednesday 28th June, 2017 

 

Pneumococcal Molecular Microbiology and Competence Chair: Jeremy Brown

 

9.00-9.30                PL3 Natural transformation in streptococci: pheromones and fratricins

                               Leiv Sigve Håvarstein, Faculty of Chemistry, Biotechnology and Food Science, University of Norway


9.30-9.45                O3.1. Co-culture of S. pneumoniae strains fosters large recombination events. 

                               Donald A. Morrison, Department of Biological Sciences, University of Illinois at Chicago, Chicago, USA


9.45-10.00              O3.2.   Broad substrate range of peptide ABC exporters mediate bidirectional crosstalk between the competence and pneumocin systems in

                               Streptococcus pneumoniae. 

                               Charles Wang, University of Michigan Medical School, Ann Arbor, MI, USA


10.00-10.15            O3.3. Pneumococcal competence, an individual decision locking the fate of proximal neighboring cells? 

                               Marc Prudhomme, Université Paul Sabatier Toulouse 3, Toulouse, France


10.15-10.30            O3.4. Regulation and characterization of a novel, competence-responsive pneumococcal peptide implicated in biofilm development. 

                               Surya Aggarwal,Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, P.A., USA

 

10.30-11.00            Coffee break

 

Pneumococcal Pathogenesis 1 Chair: Birgitta Henriques Normark and Federico Iovino

 

11.00-11.30            PL4 Pneumococcal replication in splenic macrophages, a critical phase preceding invasive infection. 

                               Marco R. Oggioni, Department of Genetics, University of Leicester, Leicester, UK


11.30-11.45            O4.1. A role for splenic macrophages in protecting pneumococci from neutrophil-mediated clearance. 

                               Joe Wanford, Department of Genetics, University of Leicester, Leicester, UK


11.45-12.00            O4.2. Pneumolysin-mediated ion dysregulation leads to necroptosis of lung epithelial cells. 

                               Carlos J. Orihuela, Department of Microbiology, The University of Alabama at Birmingham, Birmingham, USA

 

12.00-13.00            Lunch

 

13.00-13.15            O4.3. Von Willebrand factor as endothelial foothold for Streptococcus pneumoniae in the blood flow. 

                               Hilger Jagau, Technische Universität Braunschweig, Braunschweig, Germany


13.15-13.30            O4.4. Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, Small Colony Variant and determine the outcome of its interactions

                               in co-culture with Haemophilus influenzae. 

                               Alexandra Tikhomirova, Research Centre for Infectious Disease, Australian Centre for Antimicrobial Resistance Ecology and School of Biological 

                               Sciences, The University of Adelaide, Adelaide, Australia, Adelaide, Australia


13.30-13.45            O4.5  Streptococcus pneumoniae that invade the heart form biofilms and are distinct from pneumococci in the bloodstream. 

                               Anukul Shenoy,Department  of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA


13.45-14.00            O4.6 Terminal domains D3 and D4 of Streptococcus pneumoniae pilus-1 tip protein RrgA mediate human fibronectin interaction displaying a two domain                                binding mechanism. 

                               Tanja Becke, FG Protein Biochemistry & Cellular Microbiology, University Applied Sciences Munich, München, Germany

 

14.00-16.00            Coffee and Poster session

 

Pneumococcal Pathogenesis 1 continued Chair: Marco R. Oggioni

 

16.00-16.30            PL5. Pneumococcal signals driving fetal neurodevelopment. 

                               Elaine Tuomanen, Dept of infectious diseases, St Jude Children's Research, Hospital, Memphis, TN, USA


16.30-16.45            O5.1. pIgR and PECAM-1 receptors interact with pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion. 

                               Federico Iovino, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden


16.45-17.00            O5.2. Towards a further understanding of the pathogenesis underlying pneumococcal meningitis. 

                               Marie Yang, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom


17.00-17.15            O5.3. A proteomics approach to decipher pneumococcal adaptation during CSF infection. 

                               Sven Hammerschmidt, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany


17.15-17.30            O5.4. Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence. 

                               Hasan Yesilkaya, Deparment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK

 

17:30                      Buses leave from the conference venue to the City Hall 

                               Stockholm City and Stockholm County is hosting the Europneumo conference 2017 reception with guided tour at the City Hall (Home of the Nobel 

                               banquet).

 

 

Thursday June 29th

 

Pneumococcal pathogenesis 2 Chair: Jan Willem Veening and Peter Mellroth

 

9.00-9.30                PL6. Bacterial and Host Factors in Pneumococcal Transmission.

                               Prof Jeff Weiser, Department of Microbiology, New York University


9.30-9.45                O6.1 AliC and AliD alter protein expression and contribute to persistence of nonencapsulated Streptococcus pneumoniae. 

                               Larry McDaniel, University of Mississippi Medical Center, Jackson, USA


9.45-10.00              O6.2 Deciphering the vocabulary and etymology of the pneumococcal language

                               N. Luisa Hiller, Carnegie Mellon University, Pittsburgh, USA


10.00-10.15            O6.3 Whole blood killing of Streptococcus pneumoniae:  a versatile assay to determine bacterial and host factors affecting opsonophagocytosis. 

                               Jeroen Langereis, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands


10.15-10.30            O6.4 Desialylation of platelets by neuraminidase A from Streptococcus pneumoniae induces platelet hyper-reactivity. 

                                Marien I. de Jonge, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

 

10.30-11.00            Coffee break

 

11.00-11.15            O6.5. Identification of pneumococcal transmission factors in virally co-infected ferrets. 

                               Jason Rosch, St Jude Children's Research Hospital, Memphis, USA


11.15-11.30            O6.6 Do Streptococcus pneumoniae and respiratory Syncytia virus synergize to promote invasive disease? 

                               Shadia Khandaker, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK


11.30-11.45            O6.7 Mechanism for enhanced bacterial burden in the lower respiratory tract of mice during influenza/pneumococcal coinfection

                               Vicky Sender, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden


11.45-12.00            O6.8 Effect of influenza-like-illness on Streptococcus pneumoniae presence in the upper-respiratory-tract of adults aged over 60 years. 

                               Krzysztof Trzcinski, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands

 

12.00-13.00            Lunch

 

Vaccinology and Immunology Chair: Aras Kadioglu

 

13.00-13.30            PL7 Adaptive immunity to Streptococcus pneumoniae. 

                               Jeremy Brown, Division of Infection and Immunity, University College London, London, UK


13.30-13.45            O7.1 The relationship between Streptococcus pneumoniae carriage and antimicrobial resistance following introduction of PCV-13 in Malawi: the use of                                  DNA-microarray and Bayesian networks

                               Andrea Gori, Division of Infection and Immunity, University College London, London, UK


13.45-14.00            O7.2 Streptococcus mitis-specific antibodies show cross-reactivity with a range of virulent Streptococcus pneumoniae serotypes

                               Sudhanshu Shekhar, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway


14.00-14.15            O7.3 Chronic soil-transmitted helminth infection impairs host immune control of Streptococcus pneumoniae nasopharyngeal carriage. 

                               Alice Low,Institute of Infection and Global Health, University of Liverpool, Liverpool, UK


14.15-14.30            O7.4 Intranasal vaccination with lipoproteins confers protection against pneumococcal colonization

                               Franziska Voß, Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany

 

14.30-16.30            Coffee and Poster session

 

16.30-16.45            O7.5 Functional effects of regulatory T cells on macrophage inflammatory responses to Streptococcus pneumoniae

                               Gabriella Szylar, Division of Infection and Immunity, University College London, London, United Kingdom


16.45-17.00            O7.6 Pneumolysin at sub-lytic doses inhibits cytokine responses via interaction with a novel receptor in human dendritic cells 

                               Karthik Subramanian, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

 

18.00                      Conference dinner at Restaurant Jöns Jakob at Karolinska Institutet 

 

Friday June 30th

 

Pneumococcal cell biology, structural biology Chair: Staffan Normark

 

9.00-9.30                PL8 Identification of a unique cell cycle regulator in Streptococcus pneumoniae by en masse GFP localization, Tn-seq and CRISPRi phenotyping 

                               Jan-Willem Veening, Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland


9.30-9.45                O8.1 Identification of the Lipoteichoic Acid Ligase in Streptococcus pneumoniae

                               Franziska Waldow, Research Center Borstel, Leibniz-Center of Medicine and Biosciences, Borstel, Germany


9.45-10.00              O8.2 The protein-kinase StkP and the cell division of Streptococcus pneumoniae

                               Christophe Grangeasse, CNRS - Université de Lyon, Lyon, France


10.00-10.15            O8.3 Modular architecture and unique recognition features in the modular CbpL contributing to pneumococcal pathogenesis. 

                               Juan A. Hermoso, Department of Crystallography and Structural Biology, “Rocasolano” Institute of Physical-Chemistry, CSIC, Madrid, Spain

 

10.15-10.45            Coffee break

 

10.45-11.00            O8.4 Antipneumococcal effect of peptides based on isolated choline-binding repeats.

                               Jesus Sanz, Miguel Hernandez University, Elche, Spain


11.00-11.15            O8.5 Addition of choline-binding modules (CBMs) causes aggregation and inhibition of cell separation in Streptococcus pneumoniae growth cultures.

                               Manuel Sanchez-Angulo, Miguel Hernandez University, Elche, Spain  

 

RNA, transcriptomics and Bacterial metabolism Chairs: Anders Håkansson and Edmund Loh

 

11.15-11.45            PL9 CRISPR-Cas9: a transformative genome engineering technology in life sciences

                               Emmanuelle Charpentier, Max Planck Institute for Infection Biology, Berlin, Germany and (MIMS), Umeå University, Sweden


11.45-12.00            O9.1 The organization and dynamics of the pneumococcal transcriptome

                               Rieza Aprianto, Groningen Biomolecular Sciences and Biotechnology Institute, Centre for Synthetic Biology, University of Groningen, The Netherlands


12.00-12.15            O9.2 Role of glycolysis during Streptococcus pneumoniae death induced by the human milk-protein lipid complex (HAMLET). 

                               Goutham Vansarla, Department of Translational Medicine, Lund University, Malmö, Sweden Kolla med Anders H


12.15-12.30            O9.3 Gene expression profiling of the pneumococcal phage SpSL1 during the lytic and lysogenic cycle. 

                               Marco Oggioni, Department of Genetics, University of Leicester, Leicester, United Kingdom


12.30-12.45            Concluding remarks. Birgitta Henriques-Normark, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

 

12.45-14.00            Lunch